SARS : clinical presentation, transmission, pathogenesis and treatment options
Identifieur interne : 004417 ( Main/Exploration ); précédent : 004416; suivant : 004418SARS : clinical presentation, transmission, pathogenesis and treatment options
Auteurs : Paul K. S. Chan [Hong Kong] ; Julian W. Tang [Hong Kong] ; David S. C. Hui [Hong Kong]Source :
- Clinical science : (1979) [ 0143-5221 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- pathogénicité : Virus du SRAS.
- Pascal (Inist)
- Wicri :
- geographic : République populaire de Chine.
- topic : Homme.
English descriptors
- KwdEn :
- China, Communicable Disease Control, Communicable Diseases, Emerging, Coronavirus, Global Health, Human, Humans, Inflammation, Pathogenesis, Respiratory system infection, SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (transmission), Severe acute respiratory syndrome, Symptomatology, Transmission, Treatment.
- MESH :
- geographic : China.
- diagnosis : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- therapy : Severe Acute Respiratory Syndrome.
- transmission : Severe Acute Respiratory Syndrome.
- Communicable Disease Control, Communicable Diseases, Emerging, Global Health, Humans.
Abstract
SARS (severe acute respiratory syndrome) appeared as the first emerging infectious disease of this century. It is fortunate that the culprit virus can be grown without much difficulty from a commonly used cell line, allowing an unlimited supply of isolates for further molecular studies and leading to the development of sensitive diagnostic assays. How the virus has successfully jumped the species barrier is still a mystery. The superspreading events that occurred within hospital, hotel and high-density housing estate opens a new chapter in the mechanisms and routes of virus transmission. The old practice of quarantine proved to be still useful in controlling the global outbreak. Despite all the available sophisticated tests, alertness with early recognition by healthcare workers and prompt isolation of suspected cases is still the most important step for containing the spread of the infection. Although the rapidly evolving outbreak did not allow the conducting of systematic clinical trails to evaluate treatment options, the accumulated experience on managing SARS patients will improve the clinical outcome should SARS return. Although SARS led to more than 700 deaths worldwide, the lessons learnt have prepared healthcare systems worldwide to face future emerging and re-emerging infections.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000554
- to stream PascalFrancis, to step Curation: 000436
- to stream PascalFrancis, to step Checkpoint: 000435
- to stream Main, to step Merge: 004636
- to stream PubMed, to step Corpus: 002383
- to stream PubMed, to step Curation: 002383
- to stream PubMed, to step Checkpoint: 002014
- to stream Ncbi, to step Merge: 001333
- to stream Ncbi, to step Curation: 001333
- to stream Ncbi, to step Checkpoint: 001333
- to stream Main, to step Merge: 003E93
- to stream Main, to step Curation: 004417
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">SARS : clinical presentation, transmission, pathogenesis and treatment options</title><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Tang, Julian W" sort="Tang, Julian W" uniqKey="Tang J" first="Julian W." last="Tang">Julian W. Tang</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0091530</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0091530 INIST</idno><idno type="RBID">Pascal:06-0091530</idno><idno type="wicri:Area/PascalFrancis/Corpus">000554</idno><idno type="wicri:Area/PascalFrancis/Curation">000436</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000435</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000435</idno><idno type="wicri:doubleKey">0143-5221:2006:Chan P:sars:clinical:presentation</idno><idno type="wicri:Area/Main/Merge">004636</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16411895</idno><idno type="wicri:Area/PubMed/Corpus">002383</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002383</idno><idno type="wicri:Area/PubMed/Curation">002383</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002383</idno><idno type="wicri:Area/PubMed/Checkpoint">002014</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002014</idno><idno type="wicri:Area/Ncbi/Merge">001333</idno><idno type="wicri:Area/Ncbi/Curation">001333</idno><idno type="wicri:Area/Ncbi/Checkpoint">001333</idno><idno type="wicri:doubleKey">0143-5221:2006:Chan P:sars:clinical:presentation</idno><idno type="wicri:Area/Main/Merge">003E93</idno><idno type="wicri:Area/Main/Curation">004417</idno><idno type="wicri:Area/Main/Exploration">004417</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">SARS : clinical presentation, transmission, pathogenesis and treatment options</title><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Tang, Julian W" sort="Tang, Julian W" uniqKey="Tang J" first="Julian W." last="Tang">Julian W. Tang</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author></analytic><series><title level="j" type="main">Clinical science : (1979)</title><title level="j" type="abbreviated">Clin. sci. : (1979)</title><idno type="ISSN">0143-5221</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical science : (1979)</title><title level="j" type="abbreviated">Clin. sci. : (1979)</title><idno type="ISSN">0143-5221</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>China</term><term>Communicable Disease Control</term><term>Communicable Diseases, Emerging</term><term>Coronavirus</term><term>Global Health</term><term>Human</term><term>Humans</term><term>Inflammation</term><term>Pathogenesis</term><term>Respiratory system infection</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Severe acute respiratory syndrome</term><term>Symptomatology</term><term>Transmission</term><term>Treatment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chine</term><term>Contrôle des maladies contagieuses</term><term>Humains</term><term>Maladies transmissibles émergentes</term><term>Santé mondiale</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (transmission)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Communicable Disease Control</term><term>Communicable Diseases, Emerging</term><term>Global Health</term><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chine</term><term>Contrôle des maladies contagieuses</term><term>Humains</term><term>Infection appareil respiratoire</term><term>Maladies transmissibles émergentes</term><term>Santé mondiale</term><term>Syndrome respiratoire aigu sévère</term><term>Symptomatologie</term><term>Transmission</term><term>Pathogénie</term><term>Traitement</term><term>Coronavirus</term><term>Inflammation</term><term>Homme</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SARS (severe acute respiratory syndrome) appeared as the first emerging infectious disease of this century. It is fortunate that the culprit virus can be grown without much difficulty from a commonly used cell line, allowing an unlimited supply of isolates for further molecular studies and leading to the development of sensitive diagnostic assays. How the virus has successfully jumped the species barrier is still a mystery. The superspreading events that occurred within hospital, hotel and high-density housing estate opens a new chapter in the mechanisms and routes of virus transmission. The old practice of quarantine proved to be still useful in controlling the global outbreak. Despite all the available sophisticated tests, alertness with early recognition by healthcare workers and prompt isolation of suspected cases is still the most important step for containing the spread of the infection. Although the rapidly evolving outbreak did not allow the conducting of systematic clinical trails to evaluate treatment options, the accumulated experience on managing SARS patients will improve the clinical outcome should SARS return. Although SARS led to more than 700 deaths worldwide, the lessons learnt have prepared healthcare systems worldwide to face future emerging and re-emerging infections.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="Hong Kong"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><name sortKey="Tang, Julian W" sort="Tang, Julian W" uniqKey="Tang J" first="Julian W." last="Tang">Julian W. Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004417 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004417 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:06-0091530
|texte= SARS : clinical presentation, transmission, pathogenesis and treatment options
}}
| This area was generated with Dilib version V0.6.33. |  |